Abstract

Anti-Arthritic And Anti Inflammatory Activity Of Beta Caryophyllene Against Freund's Complete Adjuvant Induced Arthritis In Wistar Rats

Aim of the study: Beta-Caryophyllene is a potent phyto cannabinoid which is reported to have anti-inflammatory activity. In view of its potent antiinflammatory activity, the present study was designed to evaluate its antiarthritic activity.

Materials and strategies: The Beta-Caryophyllene was tested against Complete Freund’s adjuvant (CFA) induced arthritic rats. Arthritis assessment, paw volume were measured. And radiological examination was performed. On day 22, the animals were sacrificed; Hind paw joint was extracted for histopathology and biochemical parameters like antioxidants, total protein, lipid peroxidation, serum nitrates, SGOT, SGPT, ALP, and Bilirubin were examined.

Results: Beta-Caryophyllene significantly decreased the arthritis which was evident with arthritis index, paw volume as well as the maintenance of biochemical parameters. The histopathology and radiology also revealed the control in inflammation with Beta-Caryophyllene.

Conclusion: The present study is suggestive that Beta-Caryophyllene has prominent anti-arthritic activity which may be attributed to its antiinflammatory activity.


Author(s):

Vijayalaxmi A, Vasudha Bakshi and Nazia Begum



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