Sarcomatous Transformation in the Paget's Disease: A Case Report with a Review of Literature

The dreaded consequence of Paget’s disease is sarcomatous transformation, a neoplasm with poor prognosis. This report describes a 61-year-old patient who developed two sarcoma in Paget disease: the first on right distal humerus and the second on right clavicle. Time elapsed beetwen lesions was 5 years. Clavicle’s tumor should be considered as metastasis, but in our opinion, some interesting elements support theory of a second primitive tumor with a metachromous onset. We present clinical, radiological and pathological features of this case comparing it with a review of literature.


Gabriele Drago, Roberto Casadei and Davide Maria Donati

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