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Antibodies to Sclerostin or G-CSF Receptor Partially Eliminate Bone or Marrow Adipocyte Loss

Phaedra Zwerina*

Department of Oncology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

*Corresponding Author:
Phaedra Zwerina
Department of Oncology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel
E-mail:[email protected]

Received date:  December 12, 2022, Manuscript No. IPJBRR-22-15872; Editor assigned date: December 14, 2022, PreQC No. IPJBRR-22-15872(PQ); Reviewed date: December 23, 2022, QC No. IPJBRR-22-15872; Revised date: January 02, 2022, Manuscript No. IPJBRR-22-15872(R); Published date: January 12, 2022, DOI: 10.36648/ IPJBRR.9.1.69
Citation: Zwerina P (2022) Antibodies to Sclerostin or G-CSF Receptor Partially Eliminate Bone or Marrow Adipocyte Loss. Bone Rep Recommendations Vol.9 No.1: 69.

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Lacuno-Canalicular Network

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Mineral Homeostasis

The fact that the stress–strain behavior that was obtained for the various models that were introduced was significantly different attests to the significance of the microstructure of the bone tissue for its failure behavior. The results highlighted the effect of cement lines on the crack deflection path and global fracture behavior of the bone microstructure when considering the role of interfaces. The behavior of bone fractures was also influenced by bone micromorphology and the area fraction of cortical bone tissue components like osteons, cement lines, and pores; particularly, increased porosity decreased the maximum stress required to initiate crack propagation, thereby altering the path that cracks take. In bone fracture, therefore, cement line structure, mineralization, and areal fraction are significant parameters. Using cryo-3D printing and dipping, a hierarchical scaffold with a two-stage drug release strategy is made. The scaffold has antibacterial and osteogenic properties thanks to the combination of osteogenic peptide and [email protected] oxide. In vitro, the multifunctional scaffold has synergistic antibacterial and osteogenic effects. In a critical-sized, infected mandibular bone defect, the scaffold successfully regenerates the bone tissue in vivo. Sadly, bariatric surgeries are also linked to negative side effects like bone loss and an increased risk of fracture. Because these insights have the potential to uncover novel therapeutic targets, it is essential to investigate the mechanisms underlying the bone loss caused by bariatric surgery. Vertical sleeve gastrectomy, which removes a significant portion of the stomach along the greater curvature, is the most common type of bariatric surgery. Our previous research used a mouse model to demonstrate that VSG impairs osteoid mineralization and bone formation, which results in the loss of trabecular and cortical bone.

Breast cancer kills more women than any other cancer, affecting approximately one in twelve women. Osteolytic bone metastases and excessive bone resorption are associated with a number of complications, including severe pain, hypercalcemia, bone fractures, spinal cord compression, and a significant decrease in the patient's quality of life. It is becoming increasingly clear that bone metastasis requires tumor cells to express bone-compatible matrix proteins and adhesion molecules, as well as interactions between tumor and stromal cells in the bone microenvironment, despite the fact that the processes controlling breast cancer metastasis prefer bone. Several local growth factors that play a role in bone turnover and metabolism are secreted by breast cancer cells, which then release growth factors stored in the bone matrix to encourage tumor growth.

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