A rare case of Dedifferentiated chondrosarcoma with osteosarcomatous and fibrosarcomatous differentiation

Neha Sethi1; Anjali Sharma2; Chaitali Singh3; Kirti P; ia4; Sanjeev Patni5

Abstract

A rare case of Dedifferentiated chondrosarcoma with osteosarcomatous and fibrosarcomatous differentiation

Introduction : Dedifferentiated chondrosarcoma (DDC) accounts for approximately 10% of chondrosarcomas. It demonstrates very aggressive behaviour with a high rate of local recurrence (LR) and systemic progression resulting in a median survival of 6 months. Very limited studies have highlighted and covered the cases of Dedifferentiated chondrosarcoma with osteosarcomatous differentiation.

Case Report : The present case was a 55-year-old male who presented to our hospital with complaints of shoulder pain, mild chest pain and dyspnea. A large chest wall mass was present with involvement of ribs and extending to left lung. The final histopathology revealed Dedifferentiated chondrosarcoma including low grade chondrosarcoma and high-grade sarcoma. High grade sarcomatous component included Osteosarcomatous and fibrosarcomatous differentiation. Patient was then given adjuvant RT.

Conclusion

We emphasize the importance of clinical, radiological and pathological investigations in the diagnosis of suspected dedifferentiated CS. Any high grade spindle cell sarcoma in a bone in an older patient should be thoroughly investigated to identify any hidden cartilaginous tumour as they carry very bad prognosis.